Hemmo Pharma
approved by US FDA & EU
Company
Anti Wrinkle
Anti Ageing
 
Anti Ageing
The basement membrane that separates the epidermis and the dermis is rich in extracellular matrix (ECM) proteins including collagens, epilugrin, laminin, fibronectin, elastins, and heparin sulfate proteoglycans. In addition to anchoring cells and organs, the ECM serves as a mediator of receptor-induced interactions between cells, guiding growth, and differentiation. Damage to the matrix causes repair to be initiated through processes such as protein synthesis and cell differentiation and proliferation.

Most of these functions are related to signaling by peptides that are released from the ECM to cells through cell membrane receptors. Chronologically, aged skin shows decreased production of new collagen and increased proteolytic activity resulting in increased collagen degradation. Senescent fibroblasts show decreased synthesis of type I collagen and proliferate at a much slower rate than fibroblasts in young skin. Therefore, peptides modeled on repair signaling sequences are being studied and developed as cosmetic ingredients.
 
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